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*                        warfarinPK1_project.mlxtran                           *
*                        February 18, 2018 at 20:07:50                         *
*                        Monolix version : 5.0.0                               *
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POPULATION PARAMETERS ESTIMATION _______________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)
ka_pop                         :     0.603      0.13      21.6
V_pop                          :       7.8      0.36      4.61
Cl_pop                         :     0.133   0.00707      5.32

Standard Deviation of the Random Effects -
omega_ka                       :     0.676     0.156      23.1
omega_V                        :     0.226    0.0365      16.1
omega_Cl                       :     0.284    0.0401      14.1

Error Model Parameters -------------------
a                              :     0.717    0.0861        12
b                              :     0.116    0.0165      14.2

Elapsed time (seconds) :     0.74
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CORRELATION MATRIX OF THE ESTIMATES ____________________________________________

Fisher by Stochastic Approximation ---------------------------------------------
Correlation Matrix :
  ka_pop   1.00000
   V_pop  -0.02007   1.00000
  Cl_pop  -0.08946  -0.01025   1.00000
omega_ka   0.21135   0.02440   0.03393   1.00000
 omega_V  -0.01126   0.06876  -0.01950   0.05837   1.00000
omega_Cl   0.00532   0.00347   0.00258  -0.02836   0.03356   1.00000
       a   0.01650  -0.05455  -0.00160  -0.04205   0.02557   0.00900   1.00000
       b  -0.02792   0.06794   0.01100   0.02458  -0.08565  -0.04457  -0.69157   1.00000
                               min       max   max/min
Eigen values           :       0.3       1.7       5.6

Elapsed time (seconds) :   0.071
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INDIVIDUAL PARAMETERS ESTIMATION _______________________________________________

Individual Parameters Estimation by Conditional Mean ---------------------------
           min        Q1    median        Q3       max
ka :     0.168     0.659     0.766     0.868      1.73
V  :      5.14      6.94      7.94      8.75      11.4
Cl :    0.0754     0.109     0.128     0.164     0.274

Elapsed time (seconds) :    0.22
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Individual Parameters Estimation by Conditional Mode ---------------------------
           min        Q1    median        Q3       max
ka :     0.167     0.547     0.603     0.646      1.42
V  :      5.13       6.9      7.83      8.59      11.4
Cl :    0.0761     0.109     0.129     0.166      0.27

Elapsed time (seconds) :   0.013
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